Implants improves the quality of life
Modern medicine has developed various implants to replace missing anatomical structure or biological function: joint prostheses, internal fixation devices, vascular prostheses, cardiac pacemakers and defibrillators, dental implants, neurosurgical shunts and breast implants.
New devices are improved and optimized with regard to biocompatibility and functionality.
With growing use of implants, modern medicine is facing an increasing risk of infections. Microorganisms on implant surface form biofilms, what makes them difficult to detect by conventional methods such as periprosthetic tissue cultures. For successful treatment of these infections accurate microbiological diagnosis is crucial. Such biofilms consist of anextracellular matrix of polymerized polysaccharide, in which bacteria are embedded.
Free-living (planktonic) bacteria are killed by antibiotics and the host defense system, while adherent (biofilm) bacteria can survive and persist in the extracellular matrix of the biofilm.
Planktonic and biofilm forms of bacteria
Biofilm on the implant surface